Capillary Electrophoresis-Frontal Analysis For The Characterization Of Drug-Metal Binding
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| Rok publikování | 2016 |
| Druh | Článek ve sborníku |
| Konference | 13 th International Interdisciplinary Meeting on Bioanalysis CECE 2016 |
| Fakulta / Pracoviště MU | |
| Citace | MICHALCOVÁ, Lenka, Mufarreh ASMARI, Zdeněk GLATZ a Sami EL DEEB. Capillary Electrophoresis-Frontal Analysis For The Characterization Of Drug-Metal Binding. Online. In František Foret, Jana Křenková, Iveta Drobníková, Karel Klepárník. 13 th International Interdisciplinary Meeting on Bioanalysis CECE 2016. Brno, Czech Republic: Institute of Analytical Chemistry of the CAS, v. v. i., Brno, Czech Republic, 2016, s. 197-199. ISBN 978-80-904959-4-4. |
| www | Oficiální stránky konference |
| Obor | Biochemie |
| Klíčová slova | capillary electrophoresis - frontal analysis; drug - metal binding |
| Popis | This study examined the possibilities of using capillary electrophoresis-frontal analysis (CE-FA) for the characterization of drug-metal binding parameters such as formation constant (Kf) and number of binding sites. Deferiprone and iron in the Fe(III) form were selected as model system. Apparent Kf values were obtained using nonlinear regression. The results provide a more quantitative picture of how this drug binds with metal and illustrate how CE FA can be used to examine drug metal interactions. |
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