Unraveling CLL Pathogenic Cellular Mechanisms Through Integrated Micro-C, Long-Read, and RNA-Seq data analysis
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Rok publikování | 2024 |
Druh | Konferenční abstrakty |
Fakulta / Pracoviště MU | |
Citace | |
Přiložené soubory | |
Popis | Chronic lymphocytic leukemia (CLL) is characterized by a highly complex genetic landscape, leading to a variety of underlying mechanisms that contribute to disease progression. Those mechanisms are not fully understoood. The next-generation sequencing (NGS) methods provide limited insight into possible disease causes when interpreted indivudually. Integrating multiple genomic methods is necessary to gain a more comprehensive picture and account for complex interactions and pathway modifications. Our goal is to investigate the relationship between genomic aberrations, structure organization and chenges in expression profile in CLL. In particular, we aim to find structural variants and spatially associated regions that could possibly interfere with gene activity in a way that could result in their expression being changed. |
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