Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
-
Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 239
2018
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Dny elektronové mikroskopie (prohlídka CF Cryo-EM)
Rok: 2018, druh: Popularizační texty
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Dynamics of the Pollen Sequestrome Defined by Subcellular Coupled Omics
Plant Physiology, rok: 2018, ročník: 178, vydání: 1, DOI
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Enantioselective Conjugate Additions of 2-Alkoxycarbonyl-3(2H)-furanones
Organic Letters, rok: 2018, ročník: 20, vydání: 22, DOI
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Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells
Angewandte Chemie International Edition, rok: 2018, ročník: 57, vydání: 8, DOI
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Extension of the 'Inorganic Gel Casting' Process to the Manufacturing of Boro-Alumino-Silicate Glass Foams
Materials, rok: 2018, ročník: 11, vydání: 12, DOI
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Filter-Aided Sample Preparation Procedure for Mass Spectrometric Analysis of Plant Histones
Frontiers in Plant Science, rok: 2018, ročník: 9, vydání: SEP, DOI
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Free energy calculations on the stability of the 14-3-3 zeta protein
Biochimica et Biophysica Acta - Proteins and Proteomics, rok: 2018, ročník: 1866, vydání: 3, DOI
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Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics
Journal of Biological Chemistry, rok: 2018, ročník: 293, vydání: 34, DOI
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Generation of a Close-to-Native In Vitro System to Study Lung Cells-Extracellular Matrix Crosstalk
TISSUE ENGINEERING PART C-METHODS, rok: 2018, ročník: 24, vydání: 1, DOI
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Graphene Oxide from Improved Hummers' Method: Is This Material Suitable for Reproducible Electrochemical (Bio)Sensing?
ECS Journal of Solid State Science and Technology, rok: 2018, ročník: 7, vydání: 10, DOI